Autosomal dominant nocturnal frontal lobe epilepsy Home A-Z Health Information Health Library A-Z Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Overview Autosomal dominant nocturnal frontal lobe epilepsy is a rare genetic condition characterized by seizures that primarily occur during sleep. It originates from the frontal lobe of brain and is inherited in an autosomal dominant pattern. Thus, it has up to 75% likelihood of genetic mutation being transferred to the offsprings. Causes Mutations in CHRNA2, CHRNA4 and CHRNB2 genes Risk factors Being born with brain abnormalitiesFamily history of seizures or epilepsyDevelopmental disabilityBrain infections or infectionsSeizures in infancy or early childhood Symptoms Seizures during sleepHand clenchingArm raising or loweringVocalizationsSense of fearDizziness Specialist to approach Neurologist Diagnosis Clinical examination and family historyEEG Treatment Antiseizure medications