Diffuse Lewy body disease (DLBD) Home A-Z Health Information Health Library A-Z Diffuse Lewy Body Disease (DLBD) Overview DLBD is progressive neurodegenerative brain disease refers to condition caused by alpha synuclein deposits in brain. These deposits are called Lewy bodies. It is accounted as the second most prevalent cause of dementia after Alzheimer’s disease. Causes The exact cause is unknownSome genes may elevate the risk of developing DLDB Risk factors Age >60 yearsFemale sexFamily history Symptoms Visual hallucinations are the hallmark of DLDBMovement disorders like bradykinesia, rigidity, tremorsCognitive problems- dementia, confusion, agitationFluctuation in sensoriumSleep disordersBehaviour and mood symptoms- depression, apathy, anxiety Specialist to approach Neurologist Diagnosis Clinical examinationMRI brain showing atrophy predominantly in occipital areasPET scan to show hypometabolism in these areasBrain biopsy (not done routinely) Treatment Medications (cholinesterase inhibitors, antipsychotics, antidepressants)Speech, cognitive therapyMovement disorders treatmentNo specific cure