Hereditary neuropathy with pressure palsies (HNPP) Home A-Z Health Information Health Library A-Z Hereditary Neuropathy With Pressure Palsies (HNPP) Overview HNPP is a neurological disorder, which is autosomal dominant inherited, with an increased tendency for nerve compression at common compression sites like elbow and fibular head. Cause Caused due to mutation in PMP22 gene Risk factors Inheriting the mutated PMP22 gene from a parent Symptoms Weakness such as wrist drop/ foot drop/ weakness of small muscles of hand after prolonged posturingTingling/ numbness/ painAtrophy of musclesLoss of sensationThe weakness may persist for a few weeks or may become permanent Diagnosis Nerve conduction studies for site and severity of nerve compressionMR neurographyNerve biopsy (rarely required)Genetic testing Specialist to approach Neurologist Treatment Short course of steroids may be warrantedOrthosis and assistive devicesPhysiotherapyAvoidance of compression at common sites prone for nerve injury