Huntington’s disease Home A-Z Health Information Health Library A-Z Huntington’s Disease Overview Huntington’s disease is an untreatable, autosomal dominant genetic movement disorder. The disease shows anticipation, meaning subsequent generations are affected at an earlier age. It usually starts at 40–50 years of age. Causes CAG nucleotide repeats expansion in the huntingtin gene HTT Risk factors HereditaryChild has a 50% chance of developing if parent has itIf the child does not develop the disease, it will not be passed onNo family history identified for 1-3% of people with Huntington disease Symptoms Altered body posturesUncontrollable dance-like movements (chorea)Issues with behaviour, sentiments, and thoughtsParkinsonism (associated with juvenile onset Westphal variant)Psychiatric features (personality changes, aggressive behaviour)DystoniaDementiaProgressive weight loss Specialist to approach Neurologist Diagnosis Family history and clinical evaluation of symptomsGenetic testingMRI Brain to determine caudate head atrophy Treatment Symptomatic treatment for chorea and dystoniaAntipsychotics for behaviour managementPrevention of repetitive falls due to chorea