Oesophageal dysmotility due to gastroesophageal reflux disease (GERD) Home A-Z Health Information Health Library A-Z Oesophageal Dysmotility Due To Gastroesophageal Reflux Di... Overview GERD can lead to oesophageal motility dysfunction owing to improper closing of the lower oesophageal sphincter (LES) and subsequent stomach acid to reflux into the oesophagus. Cause Chronic acid exposure due to GERD: GERD can lead to hypotension of the LES (a condition where the LES does not maintain the pressure required to prevent the backflow of the stomach contents into the oesophagus) as well as impaired oesophageal peristalsis, often due to chronic acid exposure. Symptoms HeartburnRegurgitationChest painDysphagiaSensation of a lump in the throat Diagnosis Oesophageal manometry: This condition may manifest as reduced peristalsis and LES dysfunction in oesophageal manometry.24-hour pH monitoring: This is often employed to confirm acid reflux. Treatment Medications:Antacids, PPIs, and H2 receptor antagonists: These may be used to reduce acid production.Prokinetic agents: These agents (e.g., metoclopramide and domperidone) may be used to improve oesophageal motility.Fundoplication surgery: In some cases, fundoplication surgery to repair the LES may be considered.