Primary Aldosteronism Home A-Z Health Information Health Library A-Z Primary Aldosteronism Overview Primary aldosteronism occurs because of overproduction of aldosterone by the adrenal glands, causing high blood pressure and low levels of potassium. Causes Benign adrenal tumours or adrenal gland overactivity. Symptoms Muscle weakness, fatigue, and frequent urination. Diagnosis Blood and urine tests to measure aldosterone and renin levels as well as imaging studies to identify gland abnormalities. Treatment Medications to block aldosterone effects, lifestyle changes to manage blood pressure, and surgery to remove overactive glands or tumours. Early diagnosis and treatment are imperative to avoid complications like heart disease and kidney damage.