Sheehan’s Syndrome Home A-Z Health Information Health Library A-Z Sheehan’s Syndrome Overview Sheehan’s syndrome, known as postpartum pituitary necrosis, arises when severe blood loss during childbirth damages the pituitary gland (pea-sized organ that is situated at the base of the brain), leading to hormone deficiencies. Symptoms Fatigue, low blood pressure, weight loss, and inability to produce breast milk. Diagnosis Assessing hormone levels through blood tests and evaluating symptoms. Imaging studies may be conducted to check the pituitary gland. Treatment Hormone replacement therapy to address deficiencies, including cortisol, thyroid hormones, and sex hormones. Regular monitoring and adjusting hormone doses are necessary to manage the condition effectively. Early diagnosis and treatment are crucial for enhancing quality of life and preventing complications.