Addison’s Disease Home A-Z Health Information Health Library A-Z Addison’s Disease Overview Addison’s disease refers to a disorder arising due to the insufficient production of hormones by the adrenal glands, especially cortisol and aldosterone. Symptoms Fatigue, low blood pressure, weight loss, and skin darkening. If left untreated, it can be life-threatening. Diagnosis Blood tests to assess hormone levels and imaging studies to evaluate the adrenal glands. Treatment Lifelong hormone replacement therapy to compensate for the deficiencies. Regular monitoring and adjustment of medication doses are essential for managing the condition. Prompt recognition and treatment of adrenal crises, which can be triggered by stress or illness, are critical to prevent severe complications.