Hyperparathyroidism Home A-Z Health Information Health Library A-Z Hyperparathyroidism Overview Hyperparathyroidism occurs when the parathyroid glands tend to produce high levels of parathyroid hormone, which result in high calcium levels in the blood. It can be primary (due to gland abnormalities) or secondary (often related to chronic kidney disease). Symptoms Kidney stones, bone pain, fatigue, and depression. Diagnosis Blood tests to assess calcium and parathyroid hormone levels, as well as imaging studies to identify gland abnormalities. Treatment Depends on the cause and severity and includes monitoring, medications, and/or surgery to remove overactive glands. Managing hyperparathyroidism helps prevent complications like osteoporosis and kidney damage.