Paget's disease of bone Home A-Z Health Information Health Library A-Z Paget's Disease of Bone Overview Paget's disease of bone disrupts the body's natural process of recycling, old bone tissue is gradually replaced by new bone tissue. This can cause fragile and misshapen bones over time, particularly affecting the skull, pelvis, legs and spine. The likelihood of developing Paget's disease heightens with age and presence of family history. Potential complications include fractures, hearing loss, and pinched nerves in the spine. Symptoms Bones and joint painTingling or weakness experienced in an extremityUnexplained hearing loss, specially if it is unilateralBone deformities Treatment The primary treatment involves bisphosphonates—medications that strengthen bones weakened by conditions like osteoporosis. Surgery may be required to address complications. Many individuals with Paget's disease experience no symptoms, but when they do arise, the most frequent complaint observed is bone pain. The disease causes the body to produce new bone at an accelerated rate, resulting in less organised and weaker bones, causing pain, deformities, and even fractures.