Thyroid Nodule Home A-Z Health Information Health Library A-Z Thyroid Nodule Overview A thyroid nodule refers to a lump present in the thyroid gland. While most thyroid nodules turn out to be benign and typically harmless, it's essential to consult your doctor if you notice any unusual swelling in your neck, particularly if you experience difficulty in breathing or swallowing or changes in voice. It is crucial to assess the possibility of cancer in such cases. Diagnosis A physical exam, blood tests to assess thyroid function, evaluation of nodule with ultrasound, and fine-needle aspiration biopsy (FNAB) to check for cancer. Treatment Treatment depends on the nodule type and may include monitoring, medications to suppress nodule growth, or surgery to remove the nodule if it is cancerous or causing symptoms. Regular follow-up is important to monitor for changes in the nodule.